National Toxicology Program

National Toxicology Program

Testing Status of Theobromine - 83670


CASRN: 83-67-0

Formula: C7-H8-N4-O2

Synonyms/Common Names

  • 1H-Purine-2,6-dione,3,7-dihydro-3,7-dimethyl- (9CI)

Known Uses

Diuretic, bronchodilator, cardiotonic, principal alkaloid of cacao, cola nut & tea (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (918305)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Feed)  (RACB83073)  Completed 
    • Citation: Final Report - Theobromine: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed
    • Male and Female Mice: Swiss
    • Dose: 0, .1, .25, .5, 1.0, 2.0%; 0, .1, .25, .5%; 0, .5%; N/A.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.