National Toxicology Program

Testing Status of Anthraquinone - 84651

CASRN: 84-65-1

Formula: C14-H8-O2

Synonyms/Common Names

• 9,10-Anthracenedione

Known Uses

Intermediate in manufacture of dyes and other organics. Organic inhibitor. Catalyst. Accelerator in nickel electroplating. Improving adhesion and heat stability of tire cord. (NTP executive summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

• 4 weeks (Dosed-Feed)  (C88036)  Completed 
  • Rats: F344/N
  • Dose: R: 0, 469, 938 OR 3750 PPM; 20/SEX/GROUP.
• 13 weeks (Dosed-Feed)  (C88036)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 1875, 3750, 7500, 15000, OR 30000 PPM; R: 20/SEX/GROUP M: 10/SEX/GROUP.

Long-Term Carcinogenicity

• 2 years (Dosed-Feed)  (C88036)  Report Complete 
  • TR-494 (NIH Number: 05-3953)  (Peer Review Approval 12/09/2004A )
    Toxicology and Carcinogenesis Studies of Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Clear Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0, 469, 938, 1875, OR 3750 PPM M: 0, 833, 2500, OR 7500 PPM.

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0182)  Completed 
  • Male Rats: F344/N
  • Dose: 0.35, 3.5, 35, 350 MG/KG.
• Toxicokinetic Study (Gavage; Intravenous)  (S0558)  Completed 
  • Rats: F344/N; Mice: B6C3F1; Rats: F344/N; Mice: B6C3F1
  • Dose: SINGLE ADMINSTRATION RECORD: PRELIM: IV 4 MG/KG MICE & 2 MG/KG RAT; GAV 80 & 80 0 MG/KG MICE & 40 & 400 MG/KG RAT.

Genetic Toxicology

• Micronucleus  (404278)  Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A47616)  Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Positive 
• Salmonella  (480416)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  •  Positive 
• Salmonella  (A07496)  Completed 
  •  Negative 
• Salmonella  (A40147)  Completed 
  •  Positive 
• Salmonella  (A48640)  Completed 
  •  Negative 
• Salmonella  (A54984)  Completed 
  •  Negative 
• Salmonella  (A65343)  Completed 
  •  Negative