Testing Status of 2-Chloronitrobenzene 88733

 

CASRN: 88-73-3

Formula: C6-H4-Cl-N-O2

Synonyms/Common Names

  • 1-Chloro-2-nitrobenzene
  • o-Chloronitrobenzene

Known Uses

Chemical intermediate. Pesticide.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C62248)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 1.1, 2.3, 4.5, 9 OR 18 PPM (5/S/S).
  • 13 weeks (Inhalation)  (C62248)  Report Complete 
    • TOX-33 (NIH Number: 93-3382)
      Toxicity Studies of 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene (CASRN 100-00-5) Administered by Inhalation to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1.1, 2.3, 4.5, 9 OR 18 PPM (10/S/S).

Special Studies

  • Absorption Disposition Metabolism Elimination (Topical Application)  (S0191)  Completed 
    • Citation: Nomeir AA, Markham PM, Mongan AL, Silveira DM, Chadwick M. Effect of dose on the percutaneous absorption of 2- and 4-chloronitrobenzene in rats. Drug Metab Dispos. 1992 May-Jun;20(3):436-9.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.65, 6.5, 65 MG/KG.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0364)  Completed 
    • Male Rats: F344/N
    • Dose: 2, 20 OR 200 MG/KG.
  • Absorption Disposition Metabolism Elimination (Gavage)  (S0365)  Completed 
    • Citation: Effect of Repeated Dosing on the Disposition and Metabolism of 2-chloronitrobenzene in Geriatric Male Rats. Studies of Chemical Disposition in Mammals. Progress Report No. 11. April, 1990.
    • Male Rats: F344/N
    • Dose: 65 MG/KG.
  • Metabolism (Gavage)  (S0104)  Completed 
    • Citation: Effect of Repeated Dosing on the Disposition and Metabolism of 2-Chloronitrobenzene in Rats after Oral Administration. Studies of Chemical Disposition in Mammals. Progress Report No.8. August, 1989.
    • Male Rats: F344/N
    • Dose: 65 MG/KG REPEATED DOSE FOR 11 DAYS.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (680124)  Completed 
    • Sister Chromatid Exchange Weakly Positive 
    • Chromosome Aberrations Positive 
  • In Vitro Cytogenetics (CA/SCE)  (743462)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (571168)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Drosophila  (710996)  Completed 
    • Citation: Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A91090)  Completed 
    • Mice
    • Male Not a Valid Test 
    • Female Not a Valid Test 
  • Salmonella  (123419)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Positive 
  • Salmonella  (217675)  Completed 
    •  Positive 
  • Salmonella  (270911)  Completed 
    •  Positive 
  • Salmonella  (334206)  Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Weakly Positive 
  • Salmonella  (689524)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Gavage)  (RACB90011)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of 2-Chloronitrobenzene in CD-1 Swiss Mice II
    • Male and Female Mice: Swiss
    • Dose: 0, 20, 40, 80, 160, 320 MG/KG/DAY; 0, 40, 80, 160 MG/KG/DAY; N/A; 0, 160 MG/KG/DAY.