National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-91178

Testing Status of Decalin - 91178

 

CASRN: 91-17-8

Related: TETRALIN (CAS: 119-64-2)

Formula: C10-H18

Synonyms/Common Names

  • Naphthalene, decahydro-

Known Uses

Research chemical, solvent for naphthalene, fats, resins, oils, in motor fuel & lubricants. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C93026)  Completed 
    • Rats: F344/N; Rats: NCI Black Reiter (NBR); Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Inhalation)  (C93026)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, OR 400 PPM R: 20/SEX/GROUP M: 10/SEX/GROUP MR: 5/GROUP RENAL TOX.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C93026)  Report Complete 
    • TR-513 (NIH Number: 05-4447)  (Peer Review Approval 09/05/2002A )
      Toxicology and Carcinogenesis Studies of Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Decalin in Male NBR Rats (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: M&F MICE AND FEMALE RATS: 0, 25, 100, OR 400 PPM MALE RATS: 0, 25, 50, 100, OR 400 PPM (20 MALES); 50/SEX/SPECIES/GROUP.

Genetic Toxicology

  • Micronucleus  (A40482)  Completed 
    • Mice: B6C3F1
    • Male Weakly Positive 
    • Female Negative 
  • Salmonella  (A08124)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 7 to 14 GD Short-Term in vivo Repro. Tox. (Gavage)  (T0037)  Completed 
    • Citation: Screening of Priority Chemicals for Reproductive Hazards
    • Female Mice: Swiss
    • Dose: 2700 MG/KG BODY WEIGHT.
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