National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-96297

Testing Status of Methyl ethyl ketoxime - 96297

 

CASRN: 96-29-7

Related: CYCLOHEXANONE OXIME (100-64-1)

Formula: C4-H9-N-O

Synonyms/Common Names

  • Butanone oxime
  • 2-Butanone, oxime (8CI)(9CI)

Known Uses

Antiskinning agent in paints and varnishes

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C88009)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: RATS AND MICE: 0, 106, 312, 625, 1250, OR 2500 PPM; 5/GROUP.
  • 13 weeks (Dosed-Water)  (C88009)  Report Complete 
    • TOX-51 (NIH Number: 99-3947)  (Tox Peer Review 05/00/1998A )
      Toxicity Studies of Methyl Ethyl Ketoxime in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) (CASRN 96-29-7)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 625, 1250, 2500, 5000, OR 10000 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0148)  Completed 
    • Citation: Disposition of Methyl Ethyl Ketoxime (MEKO) in Rats After Oral, Intravenous and Dermal Administration. Project Report No. 16. Dates of Study: August 1990 - February 1991. Studies of Chemical Disposition in Mammals. October 2, 1991.
    • Male Rats: F344/N
    • Dose: ORAL:2.7, 27, 270 MG/KG; IV:27; DERM:2.7, 270.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (497671)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A79779)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (267594)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.