National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c00077

Testing Status of Captan - C00077

 

CASRN: 133-06-2

Formula: C9-H8-Cl3-N-O2-S

Synonyms/Common Names

  • FLIT 406

Known Uses

Fungicide, bacteriostat in soap (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C00077)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C00077)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: 0,500,32000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C00077)  Report Complete 
    • TR-015 (NIH Number: 77-815)  (Peer Review Approval 07/25/1977A )
      Bioassay of Captan for Possible Carcinogenicity (CASRN 133-06-2)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,2525,6050 (AVG), M: 0,8000,16000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (985028)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (162568)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 
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