Testing Status of 1-Methyl-3-nitro-1-nitroso-guanidine C01423

 

CASRN: 70-25-7

Formula: C2-H5-N5-O3

Synonyms/Common Names

  • MNNG
  • Nitroguanide
  • N-Methyl-N'-nitro-N-nitrosoguanidine (9CI)

Known Uses

Research chemical. Formerly in lab preparation of diazomethane. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • C. elegans  (S0957)  Completed 
    • C. elegans

Genetic Toxicology

  • Salmonella  (N-9054)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251

Organ Systems Toxicity

  • Preimplantation Zygote Effects  (PZEF50)  Completed 
    • Citation: Rutledge, J.C., Generoso, W.M., Shourbaji, A., Cain, K.T., Gans, M., and Oliva, J. Developmental anomalies derived from exposure of zygotes and first-cleavage embryos to mutagens. Mutation Research 296: 167-177 (1992).
    • Female Mice: C3H X C57BL
    • Mice Female Positive