National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c01489

Testing Status of Lead(2+) acetate - C01489

 

CASRN: 301-04-2

Related: LEAD ACETATE 15347-57-6

Formula: C2-H4-O2.1/2Pb

Synonyms/Common Names

  • Acetic acid, lead(2+)salt (9CI)

Known Uses

Textile dye, chemical manufacturing, water-proofing, varnishes/paints, manufacture of insecticides, scouring agent, chemical intermediate, astringent, sedative formerly used in treatment of diarrheas (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C01489B)  Completed 
    • Rats: F344/N
    • Dose: MR: 0, 10, 30, OR 100 PPM; 10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0195)  Completed 
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination  (S0472)  Completed 
    • Citation: Victery W, Miller CR, Fowler BA. Lead accumulation by rat renal brush border membrane vesicles. J Pharmacol Exp Ther. 1984 Dec;231(3):589-96.Pubmed Abstract
    • Male Rats: Sprague Dawley
  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0475)  Completed 
    • Citation: Dieter MP, Matthews HB, Jeffcoat RA, Moseman RF. Comparison of lead bioavailability in F344 rats fed lead acetate, lead oxide, lead sulfide, or lead ore concentrate from Skagway, Alaska. J Toxicol Environ Health. 1993 May;39(1):79-93.Pubmed Abstract
    • Male Rats: F344/N
  • Mechanisms  (S0473)  Completed 
    • Citation: Mistry P, Lucier GW, Fowler BA. High-affinity lead binding proteins in rat kidney cytosol mediate cell-free nuclear translocation of lead. J Pharmacol Exp Ther. 1985 Feb;232(2):462-9.Pubmed Abstract
    • Male Rats: Sprague Dawley

Genetic Toxicology

  • Mouse Lymphoma  (G09316)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Mouse Lymphoma  (G76432)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Micronucleus  (A26197)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (A54804)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    •  Negative 
  • Salmonella  (N-9008)  Completed 
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
    • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM92043)  Completed 
    • Mice: B6C3F1
  • Immunotoxicity (Gavage)  (IMM92047)  Completed 
    • Mice: B6C3F1
  • Immunotoxicity (Gavage)  (IMM92048)  Completed 
    • Rats: F344/N
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB82102)  Completed 
    • Citation: Final Report - Lead Acetate (PbAc) : Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,.125,.25,5%; N/A; N/A.
  • 120 day minimum Continuous Breeding (Legacy) (Dosed-Water)  (RACB84059)  Completed 
    • Citation: Final Report - Lead Acetate Trihydrate: Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,.5,1.0,2.0%; N/A; N/A.
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