National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c01514

Testing Status of Adriamycin - C01514

 

CASRN: 23214-92-8

Formula: C27-H29-N-O11

Synonyms/Common Names

  • Doxorubicin
  • 14-Hydroxydaunomycin

Known Uses

Medication as an antineoplastic, isolated from streptomyces (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • Dominant Lethal (Female) (Dosed-Feed)  (DLF007)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L.B. A restudy of the efficacy of adriamycin in inducing dominant lethals in mouse spermatogonia stem cells. Mutation Res. 226:61-64 (1989).
    • Female Mice: SEC X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Female) (Dosed-Feed)  (DLF008)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L.B. A restudy of the efficacy of adriamycin in inducing dominant lethals in mouse spermatogonia stem cells. Mutation Res. 226:61-64 (1989).
    • Female Mice: CH3 X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Male) (Dosed-Feed)  (DLM006)  Completed 
    • Citation: Generoso, W.M., Cain, K.T., Hughes, L.A., and Foxworth, L.B. A restudy of the efficacy of adriamycin in inducing dominant lethals in mouse spermatogonia stem cells. Mutation Res. 226:61-64 (1989).
    • Male Mice: C3H X 101
    • Mice Male Negative 
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