National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c01547

Testing Status of IPD (3,3'-iminobis-1-propanol dimethanesulfonate (ester) hydrochloride) - C01547

 

CASRN: 3458-22-8

Formula: C8-H19-N-O6-S2.Cl-H

Synonyms/Common Names

  • 1-Propanol, 3,3'-iminobis-, dimethanesulfonate (ester), hydrochloride

Known Uses

Anticancer drug

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01547)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01547)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0, 24, 192, M: 0, 40, 320 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01547)  Report Complete 
    • TR-018 (NIH Number: 78-818)  (Peer Review Approval 11/28/1977A )
      Bioassay of 3,3'-Iminobis-1-propanol Dimethanesulfonate (Ester) Hydrochloride (IPD) for Possible Carcinogenicity (CASRN 3458-22-8)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Equivocal 
      • Male Mice Equivocal 
      • Female Mice Equivocal 
    • Dose: R: 0, 12, 24, 48, M: 0, 20, 40 MG/KG/35 PER GROUP.
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