National Toxicology Program

National Toxicology Program

Testing Status of Estradiol mustard - C01570


CASRN: 22966-79-6

Formula: C42-H50-Cl4-N2-O4

Synonyms/Common Names

  • Estra-1,3,5(10)-triene-3,17-diol (17beta)-, bis(4-(bis(2-chloroethyl)amino)benzeneacetate)

Known Uses

Anticancer drug

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C01570)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Gavage)  (C01570)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0,.25,5.0, M: 0,.4,32 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C01570)  Report Complete 
    • TR-059 (NIH Number: 78-1309)  (Peer Review Approval 04/26/1978A )
      Bioassay of Estradiol Mustard for Possible Carcinogenicity (CASRN 22966-79-6)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0,.62,1.25, M: 0,15,30 MG/KG/35 PER GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.