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Testing Status of beta-Thioguanidine deoxyriboside C01581

 

CASRN: 789-61-7

Formula: C10-H13-N5-O3-S

Synonyms/Common Names

  • beta-TGdR
  • 2'-Deoxy-6-thioguanosine (9CI)

Known Uses

Anticancer drug

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01581)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01581)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: R: 0, 3, 60, M: 0, .38, 3 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01581)  Completed 
    • TR-057 (NIH Number: 78-1363)  (Peer Review Approval 02/18/1978A )
      Bioassay of ß-TGdR for Possible Carcinogenicity (CASRN 789-61-7)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal 
      • Female Rats Positive 
      • Male Mice Inadequate Study 
      • Female Mice Inadequate Study 
    • Dose: R: 0, 3.5, 7, M: 0, 1, 4 MG/KG/35 PER GROUP.