National Toxicology Program

National Toxicology Program

Testing Status of ICRF-159 - C01627


CASRN: 21416-87-5

Formula: C11-H16-N4-O4

Synonyms/Common Names

  • (Bis-4,4'-(1-methyl-1,2-ethanediyl)-2,6-piperazinedione
  • (+-)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione
  • Razoxane

Known Uses

Anticancer drug

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01627)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01627)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01627)  Report Complete 
    • TR-078 (NIH Number: 78-1328)  (Peer Review Approval 03/07/1978A )
      Bioassay of ICRF-159 for Possible Carcinogenicity (CASRN 21416-87-5)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.