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Testing Status of ICRF-159 C01627

 

CASRN: 21416-87-5

Formula: C11-H16-N4-O4

Synonyms/Common Names

  • (Bis-4,4'-(1-methyl-1,2-ethanediyl)-2,6-piperazinedione
  • (+-)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione
  • Razoxane

Known Uses

Anticancer drug

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01627)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01627)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: FR: 0, 1.2, 384, MM: 0, 2, 640 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01627)  Completed 
    • TR-078 (NIH Number: 78-1328)  (Peer Review Approval 03/07/1978A )
      Bioassay of ICRF-159 for Possible Carcinogenicity (CASRN 21416-87-5)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0, 48, 96, M: 0, 40, 80 MG/KG/35 PER GROUP.