National Toxicology Program

National Toxicology Program

Testing Status of Isophosphamide - C01638


CASRN: 3778-73-2

Formula: C7-H15-Cl2-N2-O2-P

Synonyms/Common Names

  • N,3-Bis(2-chloroethyl)tetrahydro-2H,1,3,2-oxazaphospharin-2-amine,2-oxide (9CI)

Known Uses

Anticancer agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C01638)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
  • 13-Week (Intraperitoneal Injection)  (C01638)  Completed 
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Dose: MR: 0,2.4,48, MM: 0,4,80 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C01638)  Report Complete 
    • TR-032 (NIH Number: 77-832)  (Peer Review Approval 09/26/1977A )
      Bioassay of Isophosphamide for Possible Carcinogenicity (CASRN 3778-73-2)
    • Rats: Sprague Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Positive 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0,6,12, M: 0,10,20 MG/KG/35 PER GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.