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Testing Status of o-Anthranilic acid C01730

 

CASRN: 118-92-3

Formula: C7-H7-N-O2

Synonyms/Common Names

  • Benzoic acid, o-amino-

Known Uses

Intermediate in dye synthesis, vitamins, necessary for lactation (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C01730)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C01730)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR&MM: 0, 1000, 50000 PPM/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C01730)  Completed 
    • TR-036 (NIH Number: 78-836)  (Peer Review Approval 11/28/1977A )
      Bioassay of Anthranilic Acid for Possible Carcinogenicity (CASRN 118-92-3)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Negative 
    • Dose: R: 0, 15000, 30000, M: 0, 25000, 50000 PPM/35 PER GROUP.

Genetic Toxicology

  • Chromosome Aberrations  (919747)  Completed 
    • Mice
    •  Equivocal 
  • In Vitro Cytogenetics (CA/SCE)  (313261)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Weakly Positive 
  • Mouse Lymphoma  (217797)  Completed 
    • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
    • Mice
  • Mouse Lymphoma  (879005)  Completed 
    • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
    • Mice
  • Salmonella  (988097)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Sister Chromatid Exchanges  (919747)  Completed 
    • Mice
    • Sister Chromatid  Positive