National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c02084

Testing Status of Sodium nitrite - C02084

 

CASRN: 7632-00-0

Formula: H-N-O2.Na

Synonyms/Common Names

  • Diazotizing salts
  • Nitrous acid, sodium salt

Known Uses

Chemical. Intermediate, preservative in food, manufacture azo dyes, vasodilator, antidote for cyanide poisoning (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C88007)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 375 - 5000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C88007B)  Report Complete 
    • TR-495 (NIH Number: 01-3954)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of Sodium Nitrite (CASRN 7632-00-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R&M: 0, 0.075, 0.15, OR 0.3%; 50/SEX/DOSE.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0548)  Completed 
    • Citation: Toxicokinetics of Sodium Nitrite in Rodents Amended Report II July 16, 2004
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: RATS (M & F) IV=20MG/KG, ORALLY=40 OR 80MG/KG MICE (M & F) IV=20MG/KG, ORALLY=62.5 OR 125MG/KG.

Genetic Toxicology

  • Micronucleus  (A10342)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A17282)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A52858)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (359703)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Dosed-Water)  (RACB88071)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Sodium Nitrite in Swiss CD-1 Mice
    • Male and Female Mice: Swiss
    • Dose: 0, .06, .12, .24, .36, .48%; 0, .06, .12, .24%; N/A; 0, .24%.
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