Testing Status of Nitrilotriacetic acid (NTA) C02766

 

CASRN: 139-13-9

Formula: C6-H9-N-O6

Synonyms/Common Names

  • N,N-bis(carboxymethyl)gycine (9CI)
  • NTA

Known Uses

Chelating agent; detergents; water and textile treatment; metal plating; pulp and paper processing

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C02766)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C02766)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 31600, M: 0, 21600/30 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Dosed-Feed)  (C02766)  Report Complete 
    • TR-006 (NIH Number: 77-806)  (Peer Review Approval 03/25/1977A )
      Bioassays of Nitrilotriacetic Acid (NTA) and Nitrilotriacetic Acid, Trisodium Salt, Monohydrate (Na3-NTA-H2O) for Possible Carcinogenicity (CASRN 139-13-9) (NTA) (CASRN 18662-53-8) (Na3-NTA-H2O)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Positive 
      • Male Mice Positive 
      • Female Mice Positive 
    • Dose: R: 0, 7500, 15000, M: 0, 2500, 5000, 7500, 15000 PPM/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (267428)  Completed 
    • Citation: Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro II: Results with 20 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 60-94
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Drosophila  (536911)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Equivocal 
  • Drosophila  (879097)  Completed 
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Salmonella  (792120)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative