National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c03190

Testing Status of Amsacrine - C03190

 

CASRN: 51264-14-3

Formula: C21-H19-N3-O3-S

Synonyms/Common Names

  • Acridinylanisidide
  • N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide

Known Uses

Cytostatic agent with anti-viral & immunosuppressive properties (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Intraperitoneal Injection)  (C03190)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R:0,2.5 M:0,10ML/KG 35/group.

Organ Systems Toxicity

  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98032)  Completed 
    • Female Mice
    • Mice Female  POSITIVE 1
    • POSITIVE 1
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.