National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c03781

Testing Status of Trimethylphosphate - C03781

 

CASRN: 512-56-1

Formula: C3-H9-O4-P

Synonyms/Common Names

  • Phosphoric acid, trimethyl ester (9CI)

Known Uses

Gasoline additive for controlling surface ignition and spark plug fouling; methylating agent, chemical intermediate in the production of polymethyl polyphosphates; flame retardant solvent for paints and polymers; catalyst in the preparation of polymers and resins. Stabilizer; antioxidant

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C03781)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C03781)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 100, 1470, M: 0, 147, 2150 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C03781)  Report Complete 
    • TR-081 (NIH Number: 78-1331)  (Peer Review Approval 03/06/1978A )
      Bioassay of Trimethylphosphate for Possible Carcinogenicity (CASRN 512-56-1)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Positive 
      • Female Rats Negative 
      • Male Mice Negative 
      • Female Mice Positive 
    • Dose: R: 0, 50, 100, M: 0, 250, 500 MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (445223)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Salmonella  (623229)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Total Reproductive Capacity  (TRC98028)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative 
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