National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c04535

Testing Status of 1,1-Dichloroethane - C04535

 

CASRN: 75-34-3

Formula: C2-H4-Cl2

Synonyms/Common Names

  • Ethylidene dichloride

Known Uses

Solvent. Cleaning agent. Fumigant. Chemical intermediate.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C04535)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
  • 13-Week (Gavage)  (C04535)  Completed 
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Dose: R: 0,562,5620, M: 0,1000,10000 MG/KG/5 PER GROUP.

Long-Term Carcinogenicity

  • 2-Year (Gavage)  (C04535)  Report Complete 
    • TR-066 (NIH Number: 78-1316)  (Peer Review Approval 01/18/1978A )
      Bioassay of 1,1-Dichloroethane for Possible Carcinogenicity (CASRN 75-34-3)
    • Rats: Osborne Mendel; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Negative 
      • Female Rats Equivocal 
      • Male Mice Negative 
      • Female Mice Equivocal 
    • Dose: MR: 0,382,764 (AVG), FR: 0,475,950 (AVG), MM: 0,1442,2885 (AVG), FM: 0,1665,3331 (AVG) MG/KG/50 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (508873)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (777132)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
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