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Testing Status of Actinomycin D C04682

 

CASRN: 50-76-0

Formula: C62-H86-N12-O16

Synonyms/Common Names

  • Actinomycin C1

Known Uses

Chemotherapeutic agent, produced by streptomyces (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04682)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04682)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04682)  Completed 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: 0, .01, .02 MG/KG/25 PER GROUP.

Genetic Toxicology

  • Micronucleus  (A99906)  Completed 
    • Mice: SB
    • Male Positive 
    • Female Positive 

Organ Systems Toxicity

  • single Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98007)  Completed 
    • Female Mice: (SEC/E X C57BL/E)F1
    • Dose: 1.0 MG/KG.