National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c04773

Testing Status of 1,3-bis(Chloroethyl)-1-nitrosourea - C04773

 

CASRN: 154-93-8

Formula: C5-H9-Cl2-N3-O2

Synonyms/Common Names

  • BCNU
  • NSC 409962

Known Uses

Chemotherapeutic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04773)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04773)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04773)  Report Complete 
    •   (Peer Review Approval 06/00/1978A ) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: R: 0, .75, 1.5, M: 0, 1.25, 2.5 MG/KG/25 PER GROUP.
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