National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c04842

Testing Status of Vinblastine - C04842

 

CASRN: 865-21-4

Formula: C46-H58-N4-O9

Synonyms/Common Names

  • Vincaleukoblastine (9CI)

Known Uses

Chemotherapeutic agent isolated from Vinca rosea (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04842)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04842)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04842)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: R: 0,.1,.2 M: 0,.09,.18 MG/KG/25 PER GROUP.
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