National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c04886

Testing Status of 6-Mercaptopurine - C04886

 

CASRN: 50-44-2

Formula: C5-H4-N4-S

Synonyms/Common Names

  • 1,7-Dihydro-6H-purine-6-thione (9CI)

Known Uses

Chemotherapeutic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04886)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04886)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04886)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (310403)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 

Organ Systems Toxicity

  • Total Reproductive Capacity  (TRC98022)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative 
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