Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 6-Mercaptopurine C04886

 

CASRN: 50-44-2

Formula: C5-H4-N4-S

Synonyms/Common Names

  • 1,7-Dihydro-6H-purine-6-thione (9CI)

Known Uses

Chemotherapeutic agent

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04886)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04886)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04886)  Completed 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: R: 0, 25, 50, M: 0, 15, 30 MG/KG/25 PER GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (310403)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 

Organ Systems Toxicity

  • Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98022)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Negative