National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c04955

Testing Status of Methyl CCNU - C04955

 

CASRN: 13909-09-6

Formula: C10-H18-Cl-N3-O2

Synonyms/Common Names

  • N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea (9CI)
  • (1-Nitrosourea-1-(2-chloroethyl)-3-(4-methylcyclohexyl)

Known Uses

Chemotherapeutic agent used to treat melanoma, cancer of brain, lung and digestive tract

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Intraperitoneal Injection)  (C04955)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss
  • 13-Week (Intraperitoneal Injection)  (C04955)  Completed 
    • Rats: Sprague Dawley; Mice: Swiss

Long-Term Carcinogenicity

  • 2-Year (Intraperitoneal Injection)  (C04955)  Report Complete 
    •   (Peer Review Approval NA) Citation: EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
    • Rats: Sprague Dawley; Mice: Swiss
    • Dose: 0, 1.5, 3.0 MG/KG/25 PER GROUP.
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