National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-c51581

Testing Status of cis-1,2-Dichloroethylene - C51581

 

CASRN: 156-59-2

Formula: C2-H2-Cl2

Synonyms/Common Names

  • cis-1,2-Dichloroethene

Known Uses

Solvent & chemical intermediate for perfumes, dyes, lacquers, thermoplastics, fats, phenols, camphor, rubber, in manufacture of pharmaceuticals, in extraction of fats & oils from fish & meat (HSDB 1990).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Microencapsulation in Feed)  (C51581B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3175, 6250, 12500, 25000, OR 50000 (5/SEX/SPECIES/GROUP).

Genetic Toxicology

  • Chromosome Aberrations  (362983)  Completed 
    • Mice
    •  Negative (Nonstandard Protocol) 
  • In Vitro Cytogenetics (CA/SCE)  (099212)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Salmonella  (252705)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Salmonella  (602090)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 
  • Sister Chromatid Exchanges  (362983)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 
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