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Testing Status of Senna (powdered) EMTDP28

 

CASRN: 8013-11-4

Formula: N/F

Synonyms/Common Names

  • Senokot

Known Uses

Herbal product, extract of senna fruit, used in laxative preparations

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C20101)  Completed 
    • Mice: C57BL/6
    • Dose: 0, 625, 1250, 2500, 5000, or 10000 ppm.
  • 39 weeks (Dosed-Feed)  (C20101B)  Completed 
    • GMM-15 (NIH Number: 12-5968)
      Toxicology Study of Senna (CASRN 8013-11-4) in C57BL/6NTac Mice and Toxicology and Carcinogenesis Study of Senna in Genetically Modified C3B6.129F1/Tac-Trp53tm1Brd N12 Haploinsufficient Mice (Feed Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 100, 300, 1000, 3000, or 10, 000 ppm; 25/sex.

Genetic Toxicology

  • Micronucleus  (GEMT28)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Negative 
  • Salmonella  (840294)  Completed 
    •  Positive 
  • Salmonella  (A09328)  Completed 
    •  Negative 
  • Salmonella  (A10901)  Completed 
    •  Negative 
  • Salmonella  (GEMT28B)  Completed 
    •  Positive