National Toxicology Program

National Toxicology Program

Testing Status of Juglone - M000012


CASRN: 481-39-0

Formula: C10-H6-O3

Synonyms/Common Names

  • Akhnot
  • C.I. Natural Brown 7
  • 1,4-Napthoquinone, 5-hydroxy-(8CI)
  • Regianin
  • Walnut extract

Known Uses

Used in dietary supplements, hair dye formulations & walnut oil stain. Industrial applications include use as a non-slip agent, air pressure propellant, & filtering agent. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0838)  Completed 
    • Citation: Chen LJ, Lebetkin EH, Burka LT. Metabolism and disposition of juglone in male F344 rats. Xenobiotica. 2005 Oct-Nov;35(10-11):1019-34.Pubmed Abstract
    • Male Rats: F344/N
  • C. elegans  (S0953)  Completed 
    • C. elegans

Genetic Toxicology

  • Salmonella  (A50290)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.