Testing Status of 1-Bromopropane M000017

 

CASRN: 106-94-5

Formula: C3-H7-Br

Synonyms/Common Names

  • n-Propyl bromide
  • Propyl bromide

Known Uses

Laboratory reagent; replacement chemical for chlorinated solvents; metal cleaning and degreasing, adhesives.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C20011)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 125, 250, 500, 1000, OR 2000 PPM; 5/SEX/SPECIES/DOSE.
  • 13 weeks (Inhalation)  (C20011)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 62.5, 125, 250, 500, OR 1000 PPM; 20/SEX/DOSE M: 0, 62.5, 125, 250, OR 500 PPM; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20011)  Completed 
    • TR-564 (NIH Number: 10-5906)  (Peer Review Approval 11/19/2009A )
      Toxicology and Carcinogenesis Studies of 1-Bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1 (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Clear Evidence 
      • Male Mice No Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 125, 250, OR 500 PPM; M: 0, 62.5, 125, OR 250 PPM; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Inhalation; Intravenous; Topical Application)  (S0829)  Completed 
    • Citation: Final Study Report. 1-Bromopropane. 01/30/2001 - 06/24/2005. June 24, 2005.
    • Male and Female Rats: F344/N; Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: IV: 5, 20, 100 mg/kg. Dermal: 100 mg/kg. INHAL: 70, 240, 800, 2700 PPM..

Genetic Toxicology

  • Micronucleus  (A52458)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A39304)  Completed 
    •  Negative 
  • Salmonella  (A96196)  Completed 
    •  Negative 
  • Salmonella  (G00017)  Completed 
    •  Negative