National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m000021

Testing Status of Prevention 3 (Melatonin) - M000021

 

CASRN: 73-31-4

Formula: C13-H16-N2-O2

Synonyms/Common Names

  • Melatonin (Prevention 3)
  • 5-Methoxy-N-acetyltryptamine

Known Uses

A hormone of the pineal gland; also produced by extra-pineal tissue that lightens the skin color in amphibians; drug/therapeutic agent. Prevention 3 is a special initiative to examine dietary intervention to prevent/delay breast cancer.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 26 weeks (Dosed-Feed)  (C20001)  Completed 
    • Mice: MMTV/NEU (Tg.Nk)
    • Dose: 0, 17, 35, 70, 140, 280, OR 560 PPM (2 FEED CONTROLS).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.