National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m000038

Testing Status of Prevention 4 (Indole-3-carbinol) - M000038

 

CASRN: 700-06-1

Formula: C9-H9-N-O

Synonyms/Common Names

  • 1H-Indole-3-methanol (9CI)
  • 3-(Hydroxymethyl)indole
  • Indole-3-carbinol (Prevention 4)

Known Uses

Natural component of brassica vegetables. Marketed as a dietary supplement and cancer preventative agent. Used in a special study to prevent/delay breast cancer

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 26 weeks (Dosed-Feed)  (C20010A)  Completed 
    • Mice: MMTV/NEU (Tg.Nk)
    • Dose: 0, 500, 1000, OR 2000 PPM; 16/GROUP.

Genetic Toxicology

  • Salmonella  (A51566)  Completed 
    •  Equivocal 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.