National Toxicology Program

National Toxicology Program

Testing Status of Prevention 4 (Curcumin) - M000039


CASRN: 458-37-7

Related: TUMERIC, OLEORESIN (10105-J)

Formula: C21-H20-O6

Synonyms/Common Names

  • 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (9CI)
  • C.I. Natural Yellow 3
  • Curcuma
  • Curcumin (Prevention 4)
  • Diferuloylmethane
  • Indian saffron
  • Merita earth
  • Souchet
  • Yellow ginger
  • Yellow root

Known Uses

Dyeing cotton, wool, silk; coloring oils & waxes; boron indicator; stain in microscopy; alkali indicator; preparing curcuma paper; food dye; analytical agent. Special study to investigate dietary intervention to prevent/delay mammary cancer.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 26 weeks (Dosed-Feed)  (C20010B)  Completed 
    • Mice: MMTV/NEU (Tg.Nk)
    • Dose: 0, 2500, 5000, OR 10000 PPM; 16/GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.