National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m000040

Testing Status of Prevention 4 (Melatonin + indole-3-carbinol) - M000040

 

CASRN: MEL+INDOLCAR

Synonyms/Common Names

  • Melatonin + indole-3-carbinol (Prevention 4)

Secondary:

  • 700-06-1 - Indole-3-carbinol
  • 73-31-4 - Melatonin
  • 73-31-4 - Prevention 1 (Melatonin)
  • 73-31-4 - Prevention 2 (Melatonin)
  • 73-31-4 - Prevention 3 (Melatonin)
  • 73-31-4 - Prevention 6 (Melatonin)
  • 700-06-1 - Prevention 4 (Indole-3-carbinol)
  • 73-31-4 - Prevention 4 (Melatonin)
  • 73-31-4 - Prevention 5 (Melatonin)

Known Uses

Prevention 4 is a special study to investigate dietary intervention to prevent/delay mammary cancer using melatonin & indole-3-carbinol combination.

Short-Term Toxicity

  • 26 weeks (Dosed-Feed)  (C20010D)  Completed 
    • Mice: MMTV/NEU (Tg.Nk)
    • Dose: MEL 0.028% OR 280 PPM + I3C 0.10% OR 1000 PPM.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.