National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m000042

Testing Status of Prevention 4 (Melatonin + curcumin) - M000042

 

CASRN: MEL+CURCUMIN

Formula: C13-H16-N2-O2 + C21-H20-O6

Synonyms/Common Names

  • Melatonin + curcumin (Prevention 4)

Secondary:

  • 458-37-7 - Curcumin
  • 73-31-4 - Melatonin
  • 73-31-4 - Prevention 1 (Melatonin)
  • 73-31-4 - Prevention 2 (Melatonin)
  • 73-31-4 - Prevention 3 (Melatonin)
  • 73-31-4 - Prevention 6 (Melatonin)
  • 458-37-7 - Prevention 4 (Curcumin)
  • 73-31-4 - Prevention 4 (Melatonin)
  • 73-31-4 - Prevention 5 (Melatonin)

Known Uses

Dyeing cotton, wool, silk; coloring oils & waxes; boron indicator; stain in microscopy; alkali indicator; preparing curcuma paper; food dye; analytical agent. Will be used in special study to investigate the dietary intervention to prevent/delay mammary cancer.

Short-Term Toxicity

  • 26 weeks (Dosed-Feed)  (C20010E)  Completed 
    • Mice: MMTV/NEU (Tg.Nk)
    • Dose: (MEL 0.028% OR 280 PPM) + (CUR 0.50% OR 5000 PPM).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.