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Testing Status of N,N-Dimethyl-p-toluidine M000059

 

CASRN: 99-97-8

Formula: C9-H13-N

Synonyms/Common Names

  • Benzenamine, N,N,4-trimethyl-
  • DMPT
  • N,N-Trimethylaniline

Known Uses

Used as a polymerization accelerator for the manufacture of bone cements & dental materials. Found in industrial glues & artificial fingernail preps. Intermediate in dye & pesticide synthesis.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 days (Gavage)  (C00059B)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 60 mg/kg/day.
  • 5 days (Gavage)  (C00059)  Completed 
    • TGMX study
    • Citation: Dunnick JK, Merrick BA, Brix A, Morgan DL, Gerrish K, Wang Y, Flake G, Foley J, Shockley KR. Molecular changes in the nasal cavity after n, n-dimethyl-p-toluidine exposure. Toxicol Pathol. 2016 Aug;44(6):835-847
    • Citation: Dunnick JK, Shockley KR, Morgan DL, Brix A, Travlos GS, Gerrish K, Michael Sanders J, Ton TV, Pandiri AR. Hepatic transcriptomic alterations for N,N-dimethyl-p-toluidine (DMPT) and p-toluidine after 5-day exposure in rats. Arch Toxicol. 2016 Sep;1-12
    • Rats: F344/NTac
    • Dose: MR: 0, 1, 6, 20, 60, or 120 mg/kg; 5/dose.
  • 13 weeks (Gavage)  (C20107)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: Rats: 0, 62.5, 125, 250, 500, or 1000 mg/kg; 20/sex/dose; Mice: 0, 15, 30, 60, 125, or 250 mg/kg; 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20107)  Completed 
    • TR-579 (NIH Number: 12-5921)  (Peer Review Approval 02/08/2012A )
      Toxicology and Carinogenesis Studies of N,N-Dimethyl-p-Toluidine (CASRN 99-97-8) in F344/N Rats and B6C3F1/N Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 6, 20, or 60 mg/kg; 50/sex/species/dose.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; IV Injection and Oral)  (S0837)  Completed 
    • Citation: Absorption, Distribution, Metabolism and Excretion of N,N-Dimethyl-p-Toluidine in Rats and Mice following Oral and Intravenous Exposure.
    • Citation: Dix KJ, Ghanbari K, Hedtke-Weber BM. Disposition of [14C]N,N-dimethyl-p-toluidine in F344 rats and B6C3F1 mice. J Toxicol Environ Health A. 2007 May 15;70(10):789-98.Pubmed Abstract
    • Citation: Kim NC, Ghanbari K, Kracko DA, Weber WM, McDonald JD, Dix KJ. Identification of urinary metabolites of orally administered N,N-dimethyl-p-toluidine in male F344 rats. J Toxicol Environ Health A. 2007 May 15;70(10):781-8.Pubmed Abstract
    • Female Rats: F344/N; Female Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 2.5 mg/kg (IV); 2.5, 25, 250 mg/kg (oral). 2.5, 25, 250 mg/kg (oral); 2.5 mg/kg (IV). 25 mg/kg.

Genetic Toxicology

  • Comet Assay  (G1104ZA)  Completed 
    • Mice
  • Micronucleus  (A29310)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G1104Z)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (A14805)  Completed 
    •  Negative 
  • Salmonella  (A41919)  Completed 
    •  Negative 

Toxicogenomics

  • 4 days Microarray Analysis (Gavage)  (T00059B)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: 60 mg/kg; 6 rats.
  • 5 days Microarray Analysis (Gavage)  (T00059)  Completed 
    • Rats: F344/N
    • Dose: 0, 1, 6, 20, 60, or 120 mg/kg; 10 rats/group.