National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m000073

Testing Status of Silver acetate - M000073

 

CASRN: 563-63-3

Formula: C2-H4-O2.Ag

Synonyms/Common Names

  • Acetic acid, silver(1+) salt
  • Silver(I) acetate
  • Silver monoacetate

Known Uses

Laboratory reagent

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (K00073C)  Completed 
    • Citation: Boudreau MD, Imam MS, Paredes AM, Bryant, MS, Cunningham, CK, Felton, RP, Jones, MY, Davis, KJ, and Olson, GR. Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. Toxicol Sci. 2016 Mar;150(1):131-60. doi: 10.1093/toxsci/kfv318. Epub 2016 Jan 5.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley
    • Dose: 30 mg/kg.
  • Toxicokinetic Study (Intravenous)  (K00073B)  Completed 
    • Citation: Boudreau MD, Imam MS, Paredes AM, Bryant, MS, Cunningham, CK, Felton, RP, Jones, MY, Davis, KJ, and Olson, GR. Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. Toxicol Sci. 2016 Mar;150(1):131-60. doi: 10.1093/toxsci/kfv318. Epub 2016 Jan 5.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley
    • Dose: 2, 6, 12 mg/kg.
  • Toxicokinetic Study (Gavage)  (K00073)  Completed 
    • Citation: Boudreau MD, Imam MS, Paredes AM, Bryant, MS, Cunningham, CK, Felton, RP, Jones, MY, Davis, KJ, and Olson, GR. Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. Toxicol Sci. 2016 Mar;150(1):131-60. doi: 10.1093/toxsci/kfv318. Epub 2016 Jan 5.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley
    • Dose: 3, 30, 90 mg/kg.

Organ Systems Toxicity

  • 6 to 19 GD Conventional Teratology (Gavage)  (TER20001)  Completed 
    • Citation: Final Study Report Developmental Toxicity Evaluation for Silver Acetate (CASRN 563-63-3) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days?
    • Citation: Final Study Report Developmental Toxicity Evaluation for Silver Acetate (CASRN 563-63-3) Administered by Gavage to Sprague-Dawley (CD®) Rats on Gestational Days?
    • Rats: Sprague Dawley
    • Dose: 0, 10, 30, OR 100 MG/KG/DAY.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP20001)  Completed 
    • Rats: Sprague Dawley
    • Dose: 0, 8, 40, 80, 160, OR 290 MG/KG/DAY.
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