National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010012

Testing Status of All-trans-retinyl palmitate - M010012

 

CASRN: 79-81-2

Formula: C36-H60-O2

Synonyms/Common Names

  • Aquasol A
  • Arovit
  • Axerophtol palmitate
  • Retinol hexadecanoate
  • Vitamin A palmitate

Known Uses

Retinol compound (vitamin A) used in skin products

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Long-Term Carcinogenicity

  • 1 year (Topical Application)  (C20117)  Report Complete 
    • TR-568 (NIH Number: 11-5910)  (Peer Review Approval 01/26/2011A )
      Photococarcinogenesis Study of Retinoic Acid and Retinyl Palmitate [CASRN 302-79-4 (All-trans-retinoic acid) and 79-81-2 (All-trans-retinyl palmitate)] in SKH-1 Mice (Simulated Solar Light and Topical Application Study)
    • Mice: SKH-1 Hairless
    • Dose: No cream; retinal palmitate: 0%, .1%, .5%, 1%, or 2%; retinoic acid: .001%.

Genetic Toxicology

  • Salmonella  (A07612)  Completed 
    •  Equivocal 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.