National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010013

Testing Status of ddI + d4T combination - M010013

 

CASRN: DDI/D4TCOMB

Related: DDI; D4T

Synonyms/Common Names

  • AIDS initiative
  • 2',3'-Didioxyinosine/2',3'-Didehydro-3'-Deoxythymidine Combination

Secondary:

  • 3056-17-5 - 2',3'-Didehydro-3'-deoxythymidine
  • 69655-05-6 - 2',3'-Dideoxyinosine (AIDS Initiative)
  • 124516-24-1 - 2',3'-Dideoxyinosine-[2',3'-3H] (AIDS initiative)

Known Uses

Combination for experimental treatment of HIV

Organ Systems Toxicity

  • 6 to 17 GD Conventional Teratology (Gavage)  (TER20201)  Completed 
    • Citation: Developmental Toxicity Evaluation of 2',3'-Dideoxyinosine (ddI; CASRN 69655-05-6) and 2',3'-Didehydro-3'-Deoxythymidine (d4T; CASRN 3056-17-5) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 16
    • Citation: Developmental Toxicity Evaluation of 2',3'-Dideoxyinosine (ddl; CASRN 69655-05-6) and 2',3'-Didehydro-3'-Deoxythymidine (d4T; CASRN 3056-17-5) Co-administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 Through 16
    • Female Mice: Swiss CD-1
    • Dose: 0/0 (MAALOX), 0/60, 0/240, 0/480, 360/0, 1440/0, 2880/0, 360/60, 1440/240, OR 2880/480 DDI/D4T MG/KG/DAY.
  • 6 to 16 GD Teratology Pilot Studies (Gavage)  (TRP20101)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0/0 (WATER), 0/0 (MAALOX TC), 0/240, 1440/0, 180/30, 360/60, 720/120, 1440/240 MG/KG/DAY OF DDI/D4T.
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