National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010041

Testing Status of Pubertal flutamide study - M010041

 

CASRN: 13311-84-7

Related: PUBERTAL STUDIES OF VINCLOZOLIN; METHOXYCHLOR; ETHINYL ESTRADIOL

Formula: C11-H11-F3-N2-O3

Synonyms/Common Names

  • Eulexin
  • Flutamide pubertal study
  • 2-Methyl-N-[4'-nitro-3'-(trifluoromethyl)phenyl]propanamide
  • M-Propionotoluidide, alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro- (8CI)

Known Uses

Antineoplastic (prostatic carcinoma); therapeutic agent; androgen antagonist

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • PND 23 to 53 Continuous Breeding (Legacy) (Gavage)  (RACB20105)  Completed 
    • Citation: Pubertal Toxicity Study of Vinclozolin, Flutamide and Phenobarbital in Male Sprague Dawley Rats and Methyxychlor, Ethinyl Estradiol and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage
    • Male Rats: Sprague Dawley
    • Dose: 0, 25, OR 50 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.