Testing Status of 2,2',4,4',5,5'-Hexabromodiphenyl ether (PBDE 153) M010078

 

CASRN: 68631-49-2

Formula: C12-H4-Br6-O

Synonyms/Common Names

  • BDE 153
  • BR 33N
  • 1,1',Oxybis[2,4,5-Tribromobenzene (9Ci)
  • PBDE 153

Known Uses

Class of additive flame retardants used since the 1960s in thermoplastics to suppress or delay combustion.

Chemical Properties

Toxicity Effects (HSDB)

Planned Carcinogenicity/Toxicity

  • GD 6 to PND 21 (gestation dams) (Gavage) Selected (C20210)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • PND 1 to PND 4 (lactation dams) (Gavage) Selected (C20210)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • PND 4 to PND 21 (female pups) (Gavage) Selected (C20210)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • PND 4 to PND 21 (male pups) (Gavage) Selected (C20210)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • 13 weeks (Gavage) Selected (C20210)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han; Mice: B6C3F1

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0895)  Completed 
    • Citation: Sanders JM, Lebetkin EH, Chen LJ, Burka LT. Disposition of 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE153) and its interaction with other polybrominated diphenyl ethers (PBDEs) in rodents. Xenobiotica. 2006 Sep;36(9):824-37.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: From 0.1 to 100 umol/kg.

Genetic Toxicology

  • Salmonella  (A07760)  Completed 
    •  Negative