National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010079

Testing Status of Sodium dichromate dihydrate (VI) - M010079

 

CASRN: 7789-12-0

Related: HEXAVALENT CHROMIUM (18540-29-9)

Formula: Cr2-O7.2Na.2H2-O

Synonyms/Common Names

  • Dichromic acid, disodium salt, dihydrate
  • Disodium dichromate dihydrate

Known Uses

Sodium dichromate dihydrate is one of a number of inorganic compounds containing hexavalent chromium (Cr VI) found in drinking water source supplies as a contaminant resulting from various industrial processes including electroplating operations, leather tanning, and textile manufacturing. Intermediate; industrial chemical

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C20114B)  Report Complete 
    • TOX-72 (NIH Number: 07-5964)  (Tox Peer Review 07/05/2006A )
      Toxicity Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice
    • Mice: AM3 (C57BL/6); Mice: B6C3F1; Mice: BALB/c
    • Dose: Male Mice: 0, 62.5, 125, or 250 mg/l.
  • 13 weeks (Dosed-Water)  (C20114)  Completed 
    • TOX-72 (NIH Number: 07-5964)
      Toxicity Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/l; 10/sex/species.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C20114)  Completed 
    • TOX-72 (NIH Number: 07-5964)  (Peer Review Approval 05/16/2007A )
      Toxicity Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice
    • TR-546 (NIH Number: 08-5887)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: M/F Rats and FM: 0, 14.3, 57.3, 172, or 516 mg/l; MM: 0, 14.3, 28.6, 85.7, or 258 mg/l.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage & Dosed-Water)  (S0941)  Completed 
    • Citation: Disposition of Oral Doses of Chromium VI and Chromium III in Male Rats and Mice. Final Project Report No. 3. Period Covered: May 2004 to April 2007. December 30, 2008.
    • Female Rats: F344/N; Female Mice: C57BL/6N
    • Dose: 1-100 mg/kg; 560 mg/L.
  • Toxicokinetic Study (Dosed-Water)  (S0830)  Completed 
    • Citation: Sodium Dichromate Dihydrate (VI) Special Report The Toxicokinetics of Sodium Dichromate Dihydrate (VI) Following 21 Study Day Administration in Drinking Water to Male B6C3F1 Mice, F344 Rats, and Hartley Guinea Pigs. February 17, 2006
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Guinea Pigs: Hartley
    • Dose: 0, 1, 3, 10, 30, 100, and 300 mg Cr/L.

Genetic Toxicology

  • Micronucleus  (A50434)  Completed 
    • Mice: BALB/c
    • Male Negative 
  • Micronucleus  (A54983)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A73280)  Completed 
    • Mice: AM3 (C57BL/6)
    • Male Positive 
  • Micronucleus  (A91250)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (A94686)  Completed 
    • Mice: AM3 (C57BL/6)
    • Male Negative 
  • Salmonella  (A06449)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (IMM20202)  Completed 
    • Female Rats/Mice: F344 And SD/B6C3F1
    • Dose: 0, 5, 20, OR 100 MG/L.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.