National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010080

Testing Status of p-Toluenesulfonamide - M010080

 

CASRN: 70-55-3

Formula: C7-H9-N-O2-S

Synonyms/Common Names

  • 4-Methylbenzenesulfonamide
  • P-TSA

Known Uses

Intermediate for pesticides and drugs; used in the production of resins & fluorescent pigments. Used in the anodizing of aluminum products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C20301)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R&M: 0, 750, 1500, 3000, 10, 000, or 30, 000 ppm.
  • 13 weeks (Dosed-Feed)  (C20301)  Completed 
    • TOX-88 (NIH Number: 16-5938)
      NTP Technical Report on the Toxicity Studies of p-Toluenesulfonamide Administered in Feed to F344/N Rats, F344/NTac Rats, and B6C3F1/N Mice (CASRN 70-55-3)
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R&M: 0, 625, 1250, 2500, 5000, or 10, 000 ppm.

Genetic Toxicology

  • Micronucleus  (F66788)  Completed 
    • Rats: F344/NTac
    • Male Negative 
    • Female Negative 
  • Micronucleus  (F79645)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A84238)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.