National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010086

Testing Status of Arsenic antioxidant mixture - M010086

 

CASRN: ANTIOXCOMBO2

Secondary:

  • NAOSPINEXTR - Antioxidant model (TRAMP) - NAO (spinach extract)
  • NAOSPINEXTR - Natural antioxidant spinach leaf extract
  • 7784-46-5 - Sodium arsenite
  • 16561-29-8 - Tetradecanoyl phorbol acetate (TPA)
  • 58-95-7 - D-alpha-Tocopheryl acetate
  • 16561-29-8 - Transgenic LECM (Tetradecanoyl phorbol acetate (TPA))

Known Uses

Special study to examine the effect of the antioxidants vitamin E acetate and natural antioxidant (NAO, spinach extract) on female homozygous Tg.AC mice treated with sodium arsenite

Short-Term Toxicity

  • 26 weeks (Dosed-Water)  (C20109B)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Dose: FEMALE MICE ONLY: (START DATES 7/00 AND 10/00) 0, 150, OR 200 MG/L SODIUM ARSENITE; NAO 80 MG/KG; VITAMIN E - 200 U/KG; TPA - .625 MG/UL; (START DATE 12/00) 0, 150, OR 200 MG/L SODIUM ARSENITE; NAO - 200 MG/KG; VITAMIN E - 200 U/KG; TPA - .625 MG/UL.
  • NTE 26 weeks (Dosed-Water)  (C20109)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: FEMALE MICE ONLY: TPA CONTROL (DERMAL); 150 MG/L SODIUM ARSENITE.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.