National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010094

Testing Status of Prilocaine hydrochloride - M010094

 

CASRN: 1786-81-8

Related: PRILOCAINE (721-50-6)

Formula: C13-H20-N2-O.Cl-H

Synonyms/Common Names

  • alpha-Propylamino-2'-methylpropionanilide hydrochloride
  • Citanest
  • N-(2-Methylphenyl)-2-(propylamino)-propanamide hydrochloride

Known Uses

Local anesthetic

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0839)  Completed 
    • Citation: Sanders JM, Abu Shakra A, Burka LT, Cunningham, ML. Mutagenicity studies of urinary metabolites from rats treated orally with local anesthetics. Environmental Mutagen Society 34th Annual Meeting, May 10–14, 2003, Miami Beach, Florida. Program Chair: David A. Eastmond, Ph.D. Environ. Mol. Mutagen. 2003;41(3):190–204. doi: 10.1002/em.10147
    • Male Rats: F344/N
    • Dose: 100 mg/kg..

Genetic Toxicology

  • Micronucleus  (A30173)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female NA 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.