National Toxicology Program

National Toxicology Program

Testing Status of Chromium picolinate monohydrate - M010098


CASRN: 27882-76-4

Related: 14639-25-9

Synonyms/Common Names

  • Chromium, tris(2-pyridinecarboxylato-kappaN1,kappaO2)-, monohydrate

Known Uses

Used as a dietary supplement for losing weight

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C99027)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 80, 240, 2000, 10000, OR 50000 PPM; 10/SEX/SPECIES.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C99027)  Completed 
    • TR-556 (NIH Number: 10-5897)  (Peer Review Approval 02/27/2008A )
      Toxicology and Carcinogenesis Studies of Chromium Picolinate Monohydrate (CASRN 27882-76-4) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 2000, 10000, OR 50000 PPM; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intraperitoneal Injection; Intravenous)  (S0818)  Completed 
    • Citation: [14C] Chromium picolinate monohydrate: Disposition and metabolism in rats and mice.
    • Rats: F344/N Charles River; Male Rats: F344/N Charles River
    • Dose: 0.2 mg/kg, 15 mg/kg.

Genetic Toxicology

  • Micronucleus  (A39797)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Salmonella  (A36230)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.