National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m010107

Testing Status of S-adenosylmethionine chloride - M010107

 

CASRN: 24346-00-7

Related: S-ADENOSYLMETHIONINE (CAS: 29908-03-0)

Formula: C15-H23-N6-O5-S.Cl

Synonyms/Common Names

  • (3S)-5'-((3-Amino-3-carboxypropyl)methylsulphonio)-5'-deoxyadenosine chloride

Known Uses

Marketed as a dietary supplement used for improved joint mobility and mood enhancement (Sauer, 1999).

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Micronucleus  (A30099)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (F30099)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
    • Female NA 
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