National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m020003

Testing Status of Nevirapine - M020003

 

CASRN: 129618-40-2

Formula: C15-H14-N4-O

Synonyms/Common Names

  • 6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-
  • Nevirapine (AIDS)
  • NVP
  • Viramune

Known Uses

Drug for treatment of AIDS

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (G02003)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (IMM20304)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 88, 176, or 266 mg/kg/day.
  • 28 days Immunotoxicity (Gavage)  (IMM20305)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 88, 176, or 266 mg/kg/day.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.