National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m020020

Testing Status of TEF transgenics (PCB 126 / PECDF mixture) - M020020

 

CASRN: TEFTGMIXTURE

Synonyms/Common Names

  • PCB 126/PECDF mixture (TEF transgenics)
  • TEF Transgenics (3,3',4,4',5-Pentachlorobiphenyl/2,3,4,7,8-Pentachlorodibenzofuran mixture)

Secondary:

  • 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126)
  • 57117-31-4 - 2,3,4,7,8-Pentachlorodibenzofuran
  • 57117-31-4 - Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran))
  • 57465-28-8 - TEF transgenics (PCB 126)
  • 57117-31-4 - TEF transgenics (PECDF)
  • 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)

Known Uses

Special evaluation of relative potency factors for papilloma induction by dioxin-like compounds in transgenic Tg.AC mice

Short-Term Toxicity

  • 26 weeks (Topical Application)  (C20201D)  Subchronic Toxicology Review 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: Female mice: 0, 36/180, 121/605, 360/1800, or 760/3800 ng/kg; 20/group; 3x/week.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.