Testing Status of Welding fumes M020021

 

CASRN: STEELWELDFUM

Known Uses

Widespread occupational exposure; evidence for toxicity of mixture and components; gaps in available health effects data

Short-Term Toxicity

  • NTP / NIOSH Interagency Agreement (IAG)  (C20221)  Completed 
    • Citation: Antonini JM, Afshari AA, Stone S, Chen B, Schwegler-Berry D, Fletcher WG, Goldsmith WT, Vandestouwe KH, McKinney W, Castranova V, Frazer DG. (2006) Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals. J Occup Environ Hyg. Apr;3(4):194-203.
    • Citation: Antonini JM, Keane M, Chen BT, Stone S, Roberts JR, Schwegler-Berry D, Andrews RN, Frazer DG, Sriram K. (2011) Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity. Nanotoxicology. Dec;5(4):700-10. 1.
    • Citation: Antonini JM, O'Callaghan JP, Miller DB. (2006) Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation. Neurotoxicology. Sep;27(5):745-51.
    • Citation: Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Chapman R, Zeidler-Erdely PC, Andrews RN, Frazer DG. (2011) Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats. Arch Toxicol. May;85(5):487-98.
    • Citation: Antonini JM, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Frazer DG (2009) Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats. Inhal Toxicol. Feb;21(3):182-92.
    • Citation: Antonini JM, Sriram K, Benkovic SA, Roberts JR, Stone S, Chen BT, Schwegler-Berry D, Jefferson AM, Billig BK, Felton CM, Hammer MA, Ma F, Frazer DG, O'Callaghan JP, Miller DB. (2009) Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure. Neurotoxicology. Nov;30(6):915-25.
    • Citation: Antonini JM, Stone S, Roberts JR, Chen B, Schwegler-Berry D, Afshari AA, Frazer DG. (2007) Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats. Toxicol Appl Pharmacol. 223:234-245.
    • Citation: Leonard SS, Chen BT, Stone SG, Schwegler-Berry D, Kenyon AJ, Frazer D, Antonini JM. (2010) Comparison of stainless steel and mild steel welding fumes in generation of reactive oxygen species. Particle Fibre Toxicol. 7:32.
    • Citation: Zeidler-Erdely PC, Batelli LA, Stone S, Chen BT, Frazer DG, Young, S-H, Erdely A, Kashon ML, Andrews R, Antonini JM. (2011) Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice. Inhal Toxicol. 23(2):112-120.