Testing Status of Trimethyltin hydroxide M020041

 

CASRN: 56-24-6

Formula: C3-H10-O-Sn

Synonyms/Common Names

  • Hydroxytrimethyltin
  • Stannane, hydroxytrimethyl-
  • Trimethylstannanol
  • Trimethylstannyl hydroxide

Known Uses

Drug/therapeutic agent; organometallic

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • Neurotoxicology Assessment  (NTA20201)  Completed 
    • acute Neurotoxicology Assessment (Intraperitoneal Injection)  (NTA20701)  Completed 
      • Male Mice: CD-1
      •    DISTRIBUTION OF TIN INTO THE BRAIN DEMONSTRATED THAT BY 6 HRS OF AN IP INJECTION, TIN LEVELS CAN BE DETECTED IN THE BRAIN OF ADULT AND ADOLESCENT MALE MICE. THE PEAK LEVEL OCCURS AT 24 HRS. A PRO-INFLAMMATORY CYTOKINE RESPONSE OF TUMOR NECROSIS FACTOR ALPHA OCCURS AS EARLY AS 6 HRS AND PEAKS AT 48 HRS COINCIDING WITH A MORPHOLOGICAL RESPONSE OF MICROGLIA. NEURONAL DEATH OF DENTATE GRANULE NEURONS IN THE HIPPOCAMPUS OCCURS BETWEEN 18 AND 48 HRS. BY 72 HRS, ACTIVE NEURONAL DEATH DIMINISHES ACCOMPANIED BY PHAGOCYTIC MICROGLIA RESPONSE. NEURONAL DEATH AND MICROGLIA RESPONSE INITIATE THE PRODUCTION OF NEURAL STEM/PROGENITOR CELLS FOR REPAIR AND REPLACEMENT OF LOST NEURONS. PHYSICAL EXERCISE OFFERS PROTECTION AGAINST THE NEURONAL DEATH. THIS IS NOT DUE TO A DECREASED LEVEL OF TIN REACHING THE BRAIN BUT RATHER ASSOCIATED WITH ACTIVE NEUROPROTECTIVE FACTORS THAT MAY TRANSLATE OVER TO A MORE GENERALIZED METHOD OF PROTECTING THE BRAIN FROM NEUROTOXIC INSULT.
      • DISTRIBUTION OF TIN INTO THE BRAIN DEMONSTRATED THAT BY 6 HRS OF AN IP INJECTION, TIN LEVELS CAN BE DETECTED IN THE BRAIN OF ADULT AND ADOLESCENT MALE MICE. THE PEAK LEVEL OCCURS AT 24 HRS. A PRO-INFLAMMATORY CYTOKINE RESPONSE OF TUMOR NECROSIS FACTOR ALPHA OCCURS AS EARLY AS 6 HRS AND PEAKS AT 48 HRS COINCIDING WITH A MORPHOLOGICAL RESPONSE OF MICROGLIA. NEURONAL DEATH OF DENTATE GRANULE NEURONS IN THE HIPPOCAMPUS OCCURS BETWEEN 18 AND 48 HRS. BY 72 HRS, ACTIVE NEURONAL DEATH DIMINISHES ACCOMPANIED BY PHAGOCYTIC MICROGLIA RESPONSE. NEURONAL DEATH AND MICROGLIA RESPONSE INITIATE THE PRODUCTION OF NEURAL STEM/PROGENITOR CELLS FOR REPAIR AND REPLACEMENT OF LOST NEURONS. PHYSICAL EXERCISE OFFERS PROTECTION AGAINST THE NEURONAL DEATH. THIS IS NOT DUE TO A DECREASED LEVEL OF TIN REACHING THE BRAIN BUT RATHER ASSOCIATED WITH ACTIVE NEUROPROTECTIVE FACTORS THAT MAY TRANSLATE OVER TO A MORE GENERALIZED METHOD OF PROTECTING THE BRAIN FROM NEUROTOXIC INSULT.
      • Dose: 2.0 or 2.4 mg/kg body wt.